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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
POLE
All Species:
14.55
Human Site:
T1248
Identified Species:
35.56
UniProt:
Q07864
Number Species:
9
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q07864
NP_006222.2
2286
261518
T1248
E
S
Q
D
L
T
P
T
V
P
W
Q
E
I
L
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_543348
2273
260734
T1241
E
S
H
D
L
E
L
T
V
P
W
Q
E
I
L
Cat
Felis silvestris
Mouse
Mus musculus
Q9WVF7
2283
262009
T1247
E
S
Q
D
I
A
L
T
V
P
W
Q
E
V
L
Rat
Rattus norvegicus
NP_001100622
1515
174729
A575
E
E
V
Y
A
S
V
A
K
V
A
D
Y
W
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_001233985
2277
260654
S1239
M
S
Q
S
L
E
L
S
Q
S
W
R
E
I
L
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001121995
2284
262166
T1246
E
T
Q
E
Q
E
L
T
Q
S
W
R
E
I
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_524462
2236
256683
A1245
D
E
E
A
Q
P
Q
A
T
T
W
R
Q
A
L
Honey Bee
Apis mellifera
XP_393171
2183
252634
N1241
E
N
E
L
E
N
A
N
K
N
W
K
D
V
L
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002328167
2221
254636
T1226
L
N
S
A
E
Q
Q
T
D
S
V
H
E
L
S
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P21951
2222
255653
L1249
S
K
R
K
R
N
Q
L
T
N
E
E
D
P
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
N.A.
90.7
N.A.
90.5
60.7
N.A.
N.A.
83.7
N.A.
80
N.A.
55.2
54.6
N.A.
N.A.
Protein Similarity:
100
N.A.
N.A.
94.6
N.A.
95
63.5
N.A.
N.A.
92
N.A.
90.2
N.A.
71.9
71.5
N.A.
N.A.
P-Site Identity:
100
N.A.
N.A.
80
N.A.
73.3
13.3
N.A.
N.A.
46.6
N.A.
46.6
N.A.
13.3
20
N.A.
N.A.
P-Site Similarity:
100
N.A.
N.A.
80
N.A.
86.6
20
N.A.
N.A.
60
N.A.
66.6
N.A.
40
53.3
N.A.
N.A.
Percent
Protein Identity:
43.5
N.A.
N.A.
N.A.
40.5
N.A.
Protein Similarity:
62.7
N.A.
N.A.
N.A.
60.1
N.A.
P-Site Identity:
13.3
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
26.6
N.A.
N.A.
N.A.
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
20
10
10
10
20
0
0
10
0
0
10
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
10
0
0
30
0
0
0
0
10
0
0
10
20
0
0
% D
% Glu:
60
20
20
10
20
30
0
0
0
0
10
10
60
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
10
0
0
0
0
0
0
0
0
10
0
0
0
% H
% Ile:
0
0
0
0
10
0
0
0
0
0
0
0
0
40
0
% I
% Lys:
0
10
0
10
0
0
0
0
20
0
0
10
0
0
0
% K
% Leu:
10
0
0
10
30
0
40
10
0
0
0
0
0
10
90
% L
% Met:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
20
0
0
0
20
0
10
0
20
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
10
10
0
0
30
0
0
0
10
0
% P
% Gln:
0
0
40
0
20
10
30
0
20
0
0
30
10
0
0
% Q
% Arg:
0
0
10
0
10
0
0
0
0
0
0
30
0
0
0
% R
% Ser:
10
40
10
10
0
10
0
10
0
30
0
0
0
0
10
% S
% Thr:
0
10
0
0
0
10
0
50
20
10
0
0
0
0
0
% T
% Val:
0
0
10
0
0
0
10
0
30
10
10
0
0
20
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
70
0
0
10
0
% W
% Tyr:
0
0
0
10
0
0
0
0
0
0
0
0
10
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _